A 501(c) organization is a group that
            is allowed to claim non-profit and tax-exempt status. Simply put, this allows the group
            to receive and spend donation without worrying about paying taxes. Many different types
            of 501(c) groups exist; at the moment there are 28 subcategories: 501(c)(1) through
            501(c)(28). They perform hundreds of different functions, including charity, religious
            work, advocacy, public service, private service, medical research, and technological
            experimentation.
A 527 organization,
            while still tax-exempt, is created specifically to advocate for or against a political
            candidate. 527s do not self-identify with any political party or figure, and so avoid
            taxation under the Federal Election commission, or the contribution limits places on
            Political Action Committees. Their function is to raise awareness and inform the public
            about little-known facts, and influence the eventual
            election.
The main advantage a 501(c) has over a 527 is
            that it can be formed for almost any purpose. While a 527 is limited in the ways it can
            spend money and cannot outright endorse a political figure, a 501(c) is not bound by the
            same rules in its pursuits. However, many 501(c) organizations
            cannot engage in political action; 501(c)(3)s are specifically
            prohibited from such. In contrast, 501(c)(4) and 501(c)(6) organizations are allowed to
            lobby and advertise in favor of specific political policies and
            figures.
To reduce the issue to its essentials, remember
            that a 527 has little other purpose than to advocate politically, while a 501(c) may use
            its main purpose -- for example, raising awareness about environmental concerns -- to
            nudge thinking towards their chosen candidate as long as they do not engage in any overt
            political activity.
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