Tuesday, July 2, 2013

What is the Punnet square to show all of the possible genotypes of the offspring of a male(no family history of Niemann type A) and woman carrier?

Niemann Pick disease Type A is a disease that is acquired
if both the alleles or copies of the gene that control the production of the enzyme acid
sphingomyelinase (ASM) are mutated in a person.


This
happens only if both the parents of the child are
carriers.


If the offspring's father is not a carrier of the
disease and therefore has normal genes and the mother is a carrier and has one mutant
allele, the child will not acquire the disease.


The Punnett
square to show all the possible genotypes
is:


....................Mother (N
M)


Father         N N         N
M


(N N)          N N         M
N


(Bold: genome of
offspring)


There is a 2 in 4 chance that the
offspring is a carrier of the disease and a 2 in 4 chance that the offspring is healthy
and does not carry any mutation of the gene that leads to the
disease.

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