Monday, October 20, 2014

What is the probability of the offspring that is a daughter having hemophilia if a man with hemophilia were to marry a woman who is not a carrier...

Hemophilia is a disorder in the way the clotting factor
VIII or IX is made by the body. The genes that control this process are found in the
X-chromosome.


Males have one X-chromosome and one
Y-chromosome while females have 2 X-chromosomes.


If a man
who has hemophilia were to have a female offspring with a woman who does not have
hemophilia, the probability of the girl child having hemophilia is
zero.


As the offspring receives the X-chromosome from her
father which has the hemophilia gene and another X-chromosome from the mother that is
normal, the daughter will be a carrier of
hemophilia.


Carriers of hemophilia can make enough of the
clotting factor to avoid serious bleeding that is associated with hemophilia, though
around 50% of carriers have a slightly increased risk of
bleeding.

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