Hemophilia is a disorder in the way the clotting factor
VIII or IX is made by the body. The genes that control this process are found in the
X-chromosome.
Males have one X-chromosome and one
Y-chromosome while females have 2 X-chromosomes.
If a man
who has hemophilia were to have a female offspring with a woman who does not have
hemophilia, the probability of the girl child having hemophilia is
zero.
As the offspring receives the X-chromosome from her
father which has the hemophilia gene and another X-chromosome from the mother that is
normal, the daughter will be a carrier of
hemophilia.
Carriers of hemophilia can make enough of the
clotting factor to avoid serious bleeding that is associated with hemophilia, though
around 50% of carriers have a slightly increased risk of
bleeding.
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